These two vitamin D metabolites (called 25-hydroxyvitamin D or 25(OH)D) are measured in serum to determine a person's vitamin D status. Ĭholecalciferol is converted in the liver to calcifediol (25-hydroxycholecalciferol) ergocalciferol is converted to 25-hydroxyergocalciferol. Instead it can be considered a hormone, with activation of the vitamin D pro-hormone resulting in the active form, calcitriol, which then produces effects via a nuclear receptor in multiple locations. As vitamin D can be synthesized in adequate amounts by most mammals if exposed to sufficient sunlight, it is not essential, so technically not a vitamin. It is activated by two protein enzyme hydroxylation steps, the first in the liver and the second in the kidneys.
#D&d 5e dmg skin
Vitamin D from the diet, or from skin synthesis, is biologically inactive. Dietary recommendations typically assume that all of a person's vitamin D is taken by mouth, as sun exposure in the population is variable and recommendations about the amount of sun exposure that is safe are uncertain in view of the skin cancer risk. Mushrooms exposed to ultraviolet light contribute useful amounts of vitamin D. and other countries, cow's milk and plant-derived milk substitutes are fortified with vitamin D, as are many breakfast cereals. Only a few foods, such as the flesh of fatty fish, naturally contain significant amounts of vitamin D. Cholecalciferol and ergocalciferol can be ingested from the diet and from supplements. The major natural source of the vitamin is synthesis of cholecalciferol in the lower layers of skin epidermis through a chemical reaction that is dependent on sun exposure (specifically UVB radiation). In humans, the most important compounds in this group are vitamin D 3 (also known as cholecalciferol) and vitamin D 2 ( ergocalciferol).
Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and many other biological effects. Rickets, osteoporosis, vitamin D deficiency
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